Intrauterine Insemination

Intrauterine insemination is one of the methods of Artificial Insemination, where the IUI success rates in treating infertility are good and favourable when compared to other techniques. It is the manual introduction of the male sperms into the female uterus or cervix with the purpose of attaining the positive pregnancy in-vivo fertilization by means of other than sexual intercourse.

It may be done from the husband’s semen (AIH -Artificial insemination husband), or from the donor (AID-Artificial Insemination Donor).

Purpose of IUI

IUI treatment for pregnancy depends on the causes such as

  • Hostile cervical mucus.
  • Cervical stenosis.
  • Oligospermia and asthenospermia.
  • Male and female immune factors.
  • Male factors like impotency or anatomical defect like hypospadias, where the normal ejaculation cannot be obtained.
  • And also in cases of unexplained infertility, where the causes for the infertility cannot be diagnosed despite of all the normal findings in both males and females.

IUI Procedure

The IUI treatment for infertility starts from the semen collection from the husband. The method followed are

  • Extraction of sperm from the seminal plasma by washing, swim-up and density gradient centrifugation methods.
  • Swim-up sperm method ensures the most motile sperms into the supernatant, as it is free from cellular debris and dead sperms.
  • About 0.3mL of washed and concentrated sperm is injected through a flexible polyethylene catheter within the uterine cavity around the time of ovulation.
  • Ovulation time can be monitored with the help of USG regularly.
  • Density gradient centrifugation refers the most highly mobile and morphological normal sperms.
  • There should be an at least 1 million of processed motile sperm count for insemination.
  • Best results are obtained with the sperm count exceeding 10million.
  • The normal sperm survive and fertilize an egg for at least 3 days and this procedure is repeated 2-3 times for a period of 2-3 days.
  • Generally 4-6 cycles of insemination with superovulation is advised.

Results of IUI

After the IUI procedure, the contraception rates are increased by 70-80% after 12 insemination cycles. The whole IUI treatment process may vary from 6-12 months normally but in some cases may also depend on the female health conditions.

The intrauterine insemination cost in India is comparatively lesser and affordable when compared to other western countries. As the success rates are high and favourable the childless couple can opt for IUI.